WHAT IS BIOCERAMIC?
Ceramics are mineral products obtained by high temperature sintering that have specific physical and chemical properties. Bioceramics are inorganic, biocompatible sintered materials. They are, therefore, perfectly suitable for using with living vertebrates because they do not cause any undesirable, organic reactions, such as inflammatory, immunological and other processes, eliminating the risk of infectious and contagious diseases, amongst other things.
WHAT IS THE BASIC COMPOSITION OF THE BIOCERAMIC, OSTEOSYNT?
OSTEOSYNT® contains around 65% hydroxyapatite and 35% tricalcium phosphate, along with traces of other minerals that the organism needs, such as magnesium, iron, etc. This composition emulates the mineral matrix.
IS OSTEOSYNT AN OSTEOCONDUCTOR?
Yes, because its differentiated geometry and its internal and external architecture are recognized to be appropriate for performing the functions of human bone matrix, setting off the osteogenesis process and cellular haptotaxis as a preferential scaffold. This is a result of its similarity to human bone.
IS OSTEOSYNT AN OSTEOINDUCTOR?
Yes, because of its capacity to enable the individual’s own proteins to be deposited, chemotaxis, penetration and the surface tension of the micropores and their geometry, since osteogenesis is geometry dependent, which is also a characteristic of Osteosynt’s intrinsic osteoinduction.
ARE THERE ANY TYPES OF REJECTION OR POST SURGICAL COMPLICATIONS?
None. OSTEOSYNT® itself does not cause any undesirable reactions on contact with the organism as it is of inorganic mineral origin and is completely biocompatible, as well as being similar to the bone mineral matrix found in vertebrates.
IS IT NECESSARY TO ADD ANY OTHER COMPONENTS?
No. The use of OSTEOSYNT®, together with good surgical technique, is sufficient to guarantee the desired results. Just add it or keep it in contact with autogenous medullary blood from the patient, since it contains the components from the patient concerned. This also eliminates the risk of any undesirable collateral reactions from the addition of any substances necessary for osteogenesis, such as proteins, cells, etc.
IS THE BIOCERAMIC, OSTEOSYNT, RESORBABLE IN THE SHORT TERM?
No. Nor should it be, because if it were, it would solubilize in the short term, rather than the long term, and would therefore be phagocyted in acute inflammatory processes. OSTEOSYNT® is not resorbable in the short term, but remains stable and permanent during the osteoinduction process until the mature bone state is reached, when it becomes a part of the organism’s natural bone renewal process. The bioceramic is, then crystallized and solubilized over the long term, by the natural bone substitution process in a way that guarantees the shape and composition of the bone that existed before, through the action of osteoclasts and osteoblasts.
WHY USE OSTEOSYNT INSTEAD OF MATERIALS THAT ARE RESORBABLE IN THE SHORT TERM?
It may be a result of old concepts linked to the use of transplants, which used to cause acute inflammatory processes when cleaning their organic parts that the idea of short-term resorbable materials comes to mind. The availability of bioceramics such as OSTEOSYNT®, has practically eliminated the use of any other type of resorbable materials, because OSTEOSYNT© contains all the elements necessary for the organism’s natural bone reconstruction process, such as the bone mineral matrix, for example, which remains behind after the resorption of the organic part that is typical of transplants.
HOW IS OSTEOSYNT APPLIED?
This is an extremely simple process. OSTEOSYNT® is so easy to apply that the professionals that use it very seldom prefer to use any other product. Even if there are any inherent technical and surgical difficulties in a given case, it is still very simple to apply the OSTEOSYNT®: just keep the bioceramic in contact with the healthy bleeding bone as this contains all the substances necessary for the process. It can be mixed beforehand, if preferred, with autogenous medullary blood as this facilitates the agglutination of the granules, when the product is in particles (granules) in the correct proportion (0.7ml/g). Use this to fill the injured area, compacting the bioceramic and keeping it confined so that the OSTEOSYNT® can do its work, enabling the revascularization of the area and leading to the formation of viable mature bone through the bone morphogenetic complex starting from the OSTEOSYNT®.
HOW LONG DOES IT TAKE FOR MATURE BONE TO FORM?
The osteogenesis process is specific to each patient and their general condition, and depends on the size of the lesion. It can take from 4 to 6 months, or up to 2 years in some cases. Our experience tells us that results are obtained much more quickly than those obtained from other techniques that had been used in the past. As it is radiopaque, it can be perfectly well monitored during the process, and physiological activity can take place in little time, depending on the site of the lesion and the stress transmitted.
WHAT CONDITIONS ARE NECESSARY FOR OSTEOINDUCTION?
OSTEOSYNT® osteoinduces if the 3 basic conditions that are necessary for osteogenesis are present:
1- The scaffold provided by OSTEOSYNT®;
2- The presence of specific mother cells;
3- The BMPs supplied by the autogenous medullary blood;
4- The mixing in of 0.7ml/g of medullary blood and permanent contact with this blood alone guarantee these conditions. This, associated to the bioceramic, forms the ideal base for enabling the osteoblasts to start up the process.
WHAT IS THE IMPORTANCE OF RESOPRPTION AND SOLUBILIZATION?
Bone neoformation depends on a structure that is capable of supporting the process without undergoing any physical alterations, until the mature bone is formed. Short term soluble and/or resorbable materials do not enable bone formation that is biologically and physiologically compatible. They do not provide the conditions for depositing the components necessary, because if there is rapid resorption and/or solubilization, the scaffold will disappear as will the essential local conditions, such as the necessary mechanical resistance of this scaffold.
WHY IS BIOCERAMIC USED?
From the answers above, it is clear that bone tissue neoformation demands certain conditions in the organism that can be supplied by bioceramics, since each product has the necessary properties and characteristics. Besides inducing bone neoformation, these materials also eliminate the possibility of infectious, contagious, auto-immune, and degenerative disease transmission, without inducing abnormal inflammatory processes. They are easy to prepare, transport and store, and have excellent cost/benefit and risk/benefit ratios.
WHY CHOOSE OSTEOSYNT®?
Of all bioceramic materials, OSTEOSYNT® was the first to be registered at the relevant agencies and to present the most important results. It is the bioceramic that has been on the market for the longest time and which has been subjected to the best analyses. There are records of case studies where this material has been used which are supported by technical, scientific and clinical evidence. It has been standardized and regulated and is now a benchmark material whose use has been authorized by the Single Health System.